Runx3 - RUNX family transcription factor 3

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including chondrocyte differentiation; regulation of alpha-beta T cell differentiation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including axon guidance; hair follicle morphogenesis; and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in chromatin; cytosol; and nuclear lumen. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]