Hyal2 - hyaluronoglucosaminidase 2

Enables enzyme binding activity; transforming growth factor beta binding activity; and virus receptor activity. Contributes to transcription coactivator activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; defense response to virus; and positive regulation of protein import into nucleus. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; multicellular organismal iron ion homeostasis; and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface and membrane raft. Is anchored component of plasma membrane. Part of RNA polymerase II transcription regulator complex. Colocalizes with anchored component of external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; lateral plate mesoderm; and respiratory system. Orthologous to human HYAL2 (hyaluronidase 2). [provided by Alliance of Genome Resources, Apr 2022]