Abcg8 - ATP binding cassette subfamily G member 8

Predicted to enable ATPase-coupled transmembrane transporter activity and protein heterodimerization activity. Predicted to contribute to ATP binding activity; ATP hydrolysis activity; and cholesterol transfer activity. Involved in several processes, including bile acid signaling pathway; lipid homeostasis; and response to muscle activity. Predicted to be located in apical plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex and receptor complex. Predicted to be active in plasma membrane. Biomarker of cholestasis and non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2022]