Hsf1 - heat shock factor 1

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of gene expression. Acts upstream of or within several processes, including embryo development; gamete generation; and negative regulation of tumor necrosis factor production. Located in cytoplasm and pronucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and immune system. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]