Hras - Harvey rat sarcoma virus oncogene

Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]