Hoxd8 - homeobox D8

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within anterior/posterior pattern specification; negative regulation of transcription by RNA polymerase II; and skeletal system morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; hindlimb bud; limb; and nervous system. Orthologous to human HOXD8 (homeobox D8). [provided by Alliance of Genome Resources, Apr 2022]