Hoxb8 - homeobox B8

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of myeloid cell differentiation and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dorsal spinal cord development; embryonic skeletal system morphogenesis; and grooming behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; extraembryonic component; genitourinary system; nervous system; and neural ectoderm. Used to study trichotillomania. Orthologous to human HOXB8 (homeobox B8). [provided by Alliance of Genome Resources, Apr 2022]