Hmbs - hydroxymethylbilane synthase

Predicted to enable several functions, including amine binding activity; hydroxymethylbilane synthase activity; and uroporphyrinogen-III synthase activity. Predicted to be involved in heme biosynthetic process; liver development; and response to xenobiotic stimulus. Predicted to be located in several cellular components, including axon; cytosol; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Predicted to colocalize with condensed chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Used to study acute intermittent porphyria. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase). [provided by Alliance of Genome Resources, Apr 2022]