Hk2 - hexokinase 2

Enables hexokinase activity. Involved in negative regulation of mitochondrial membrane permeability and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including carbohydrate phosphorylation; cellular response to leukemia inhibitory factor; and regulation of glucose import. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2). [provided by Alliance of Genome Resources, Apr 2022]