Hipk2 - homeodomain interacting protein kinase 2

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; protein serine/threonine kinase activity; and transcription corepressor activity. Contributes to transcription coactivator activity. Involved in several processes, including camera-type eye morphogenesis; protein phosphorylation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including adult walking behavior; cell surface receptor signaling pathway; and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; metanephros; paraxial mesenchyme; and sensory organ. Orthologous to human HIPK2 (homeodomain interacting protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]