Hhip - Hedgehog-interacting protein

Predicted to enable hedgehog family protein binding activity and zinc ion binding activity. Involved in negative regulation of smoothened signaling pathway and skeletal system morphogenesis. Acts upstream of or within several processes, including epithelial tube branching involved in lung morphogenesis; neuroblast proliferation; and regulation of fibroblast growth factor receptor signaling pathway. Located in cell surface. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human HHIP (hedgehog interacting protein). [provided by Alliance of Genome Resources, Apr 2022]