Hesx1 - homeobox gene expressed in ES cells

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein C-terminus binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a negative effect on canonical Wnt signaling pathway. Acts upstream of or within several processes, including ERK1 and ERK2 cascade; animal organ development; and cell surface receptor signaling pathway. Located in nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; embryo endoderm; genitourinary system; and thymus. Used to study hypopituitarism and septooptic dysplasia. Human ortholog(s) of this gene implicated in septooptic dysplasia. Orthologous to human HESX1 (HESX homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]