Herc2 - HECT and RLD domain containing E3 ubiquitin protein ligase 2

Predicted to enable SUMO binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within spermatogenesis. Located in mitochondrial inner membrane. Is expressed in several structures, including central nervous system; ganglia; and trunk. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and pigmentation disease. Orthologous to human HERC2 (HECT and RLD domain containing E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]