Hand1 - heart and neural crest derivatives expressed 1

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; and transcription coregulator binding activity. Acts upstream of or within several processes, including animal organ development; mesoderm formation; and regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; heart and pericardium; and nervous system. Used to study hypoplastic left heart syndrome. Orthologous to human HAND1 (heart and neural crest derivatives expressed 1). [provided by Alliance of Genome Resources, Apr 2022]