Gria1 - glutamate receptor, ionotropic, AMPA1 (alpha 1)

Enables AMPA glutamate receptor activity; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in long-term memory; receptor internalization; and regulation of postsynaptic membrane potential. Acts upstream of or within cellular response to ammonium ion; chemical synaptic transmission; and long-term synaptic depression. Located in several cellular components, including dendrite membrane; neuron spine; and perisynaptic space. Is integral component of postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Used to study schizoaffective disorder. Orthologous to human GRIA1 (glutamate ionotropic receptor AMPA type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]