Grb10 - growth factor receptor bound protein 10

Enables insulin receptor binding activity and signaling receptor complex adaptor activity. Involved in several processes, including negative regulation of glucose import; negative regulation of signal transduction; and positive regulation of cold-induced thermogenesis. Acts upstream of or within with a negative effect on ERK1 and ERK2 cascade and gene expression. Acts upstream of or within insulin-like growth factor receptor signaling pathway and vascular associated smooth muscle cell migration. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including branchial arch; extraembryonic component; genitourinary system; sensory organ; and ventricular layer. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Apr 2022]