Gpld1 - glycosylphosphatidylinositol specific phospholipase D1

Enables glycosylphosphatidylinositol phospholipase D activity and sodium channel regulator activity. Involved in several processes, including positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of triglyceride metabolic process. Acts upstream of or within GPI anchor release; chondrocyte differentiation; and ossification. Located in several cellular components, including extracellular matrix; extracellular space; and intracellular membrane-bounded organelle. Is expressed in several structures, including alimentary system; central nervous system; ear; genitourinary system; and skeleton. Orthologous to human GPLD1 (glycosylphosphatidylinositol specific phospholipase D1). [provided by Alliance of Genome Resources, Apr 2022]