Gnb1 - guanine nucleotide binding protein (G protein), beta 1

Predicted to enable several functions, including GTPase binding activity; alkylglycerophosphoethanolamine phosphodiesterase activity; and spectrin binding activity. Acts upstream of or within several processes, including phospholipase C-activating G protein-coupled receptor signaling pathway; retina development in camera-type eye; and sensory perception of taste. Located in photoreceptor outer segment. Part of heterotrimeric G-protein complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant non-syndromic intellectual disability 42; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]