Gna11 - guanine nucleotide binding protein, alpha 11

Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activity; and alkylglycerophosphoethanolamine phosphodiesterase activity. Involved in several processes, including cranial skeletal system development; endothelin receptor signaling pathway; and multicellular organism aging. Acts upstream of or within several processes, including cellular response to pH; phospholipase C-activating dopamine receptor signaling pathway; and regulation of melanocyte differentiation. Predicted to be located in cytosol and plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in several structures, including adrenal gland; alimentary system; cardiovascular system; central nervous system; and genitourinary system. Used to study autosomal dominant hypocalcemia 2. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11). [provided by Alliance of Genome Resources, Apr 2022]