Gfi1 - growth factor independent 1 transcription repressor

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of NF-kappaB transcription factor activity and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; inner ear development; and regulation of cell fate specification. Predicted to be located in nuclear body and nuclear matrix. Predicted to be part of transcription repressor complex. Is expressed in several structures, including gut epithelium; hemolymphoid system; liver; nervous system; and sensory organ. Used to study severe congenital neutropenia. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]