Gabra2 - gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2

Predicted to enable GABA-gated chloride ion channel activity; inhibitory extracellular ligand-gated ion channel activity; and transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Involved in inhibitory synapse assembly. Located in several cellular components, including dendrite; inhibitory synapse; and neuronal cell body. Is integral component of postsynaptic specialization membrane. Is active in GABA-ergic synapse. Is expressed in brain and lens. Human ortholog(s) of this gene implicated in alcohol use disorder; autistic disorder; and developmental and epileptic encephalopathy 78. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2). [provided by Alliance of Genome Resources, Apr 2022]