Gab2 - growth factor receptor bound protein 2-associated protein 2

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in several processes, including osteoclast differentiation; phosphatidylinositol-mediated signaling; and positive regulation of mast cell degranulation. Acts upstream of or within cell migration and integrin-mediated signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of protein-containing complex. Is expressed in basal forebrain; cerebral cortex; diencephalon; and intestine smooth muscle circular layer. Orthologous to several human genes including GAB2 (GRB2 associated binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]