Fzd4 - frizzled class receptor 4

Enables Wnt-activated receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; regulation of transcription, DNA-templated; and vasculature development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of signal transduction; and vasculature development. Located in several cellular components, including cell-cell junction; dendrite; and glutamatergic synapse. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4). [provided by Alliance of Genome Resources, Apr 2022]