Fzd1 - frizzled class receptor 1

Enables Wnt-protein binding activity. Involved in astrocyte-dopaminergic neuron signaling; negative regulation of oxidative stress-induced neuron death; and regulation of presynapse assembly. Acts upstream of or within several processes, including Wnt signaling pathway; heart morphogenesis; and negative regulation of signal transduction. Predicted to be located in cell surface and neuron projection. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Orthologous to human FZD1 (frizzled class receptor 1). [provided by Alliance of Genome Resources, Apr 2022]