Fgfr2 - fibroblast growth factor receptor 2

Enables fibroblast growth factor binding activity. Involved in fibroblast growth factor receptor signaling pathway; forebrain generation of neurons; and positive regulation of cell cycle. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of signal transduction. Located in excitatory synapse and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Used to study Beare-Stevenson cutis gyrata syndrome; Crouzon syndrome; Pfeiffer syndrome; acrocephalosyndactylia; and intestinal atresia. Human ortholog(s) of this gene implicated in several diseases, including Beare-Stevenson cutis gyrata syndrome; Jackson-Weiss syndrome; LADD syndrome; reproductive organ cancer (multiple); and synostosis (multiple). Orthologous to human FGFR2 (fibroblast growth factor receptor 2). [provided by Alliance of Genome Resources, Apr 2022]