Fgfr1 - fibroblast growth factor receptor 1

Enables SH2 domain binding activity; fibroblast growth factor binding activity; and fibroblast growth factor-activated receptor activity. Involved in forebrain development; negative regulation of transcription by RNA polymerase II; and positive regulation of cell cycle. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of animal organ morphogenesis. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Pfeiffer syndrome and otitis media. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); cleft lip; hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1). [provided by Alliance of Genome Resources, Apr 2022]