Fech - ferrochelatase

Enables several functions, including ferrochelatase activity; heme binding activity; and iron-responsive element binding activity. Acts upstream of or within several processes, including porphyrin-containing compound metabolic process; regulation of cellular macromolecule biosynthetic process; and very-low-density lipoprotein particle assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including choroid plexus; heart; integumental system; liver and biliary system; and respiratory system. Used to study erythropoietic protoporphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Apr 2022]