Cacng3 - calcium voltage-gated channel auxiliary subunit gamma 3

Enables PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in positive regulation of AMPA receptor activity. Located in dendrite; excitatory synapse; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Human ortholog(s) of this gene implicated in childhood absence epilepsy and macular degeneration. Orthologous to human CACNG3 (calcium voltage-gated channel auxiliary subunit gamma 3). [provided by Alliance of Genome Resources, Apr 2022]