F2r - coagulation factor II (thrombin) receptor

Enables G protein-coupled receptor activity; G-protein alpha-subunit binding activity; and G-protein beta-subunit binding activity. Involved in several processes, including negative regulation of renin secretion into blood stream; positive regulation of intracellular signal transduction; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including regulation of interleukin-1 beta production; response to lipopolysaccharide; and thrombin-activated receptor signaling pathway. Predicted to be located in several cellular components, including caveola; endosome; and platelet dense tubular network. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; exocrine gland; lung; and thyroid gland. Orthologous to human F2R (coagulation factor II thrombin receptor). [provided by Alliance of Genome Resources, Apr 2022]