Gli3 - GLI family zinc finger 3

Predicted to enable several functions, including beta-catenin binding activity; enzyme binding activity; and mediator complex binding activity. Involved in gland development; response to estrogen; and wound healing. Located in cytoplasm and nucleus. Biomarker of clubfoot; hypospadias; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Greig cephalopolysyndactyly syndrome; Pallister-Hall syndrome; anodontia; polydactyly; and syndactyly. Orthologous to human GLI3 (GLI family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]