Ezh2 - enhancer of zeste 2 polycomb repressive complex 2 subunit

Enables several functions, including nucleic acid binding activity; protein methyltransferase activity; and transcription corepressor activity. Involved in B cell differentiation; cell development; and regulation of circadian rhythm. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of cell differentiation; and regulation of transcription, DNA-templated. Located in pericentric heterochromatin and pronucleus. Part of ESC/E(Z) complex and chromatin silencing complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and integumental system. Used to study B-cell lymphoma; Weaver syndrome; and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in Weaver syndrome; bone cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer. Orthologous to human EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit). [provided by Alliance of Genome Resources, Apr 2022]