Erbb3 - erb-b2 receptor tyrosine kinase 3

Predicted to enable several functions, including ErbB-3 class receptor binding activity; neuregulin binding activity; and transmembrane signaling receptor activity. Acts upstream of or within several processes, including nervous system development; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cardiac muscle tissue development. Located in apical plasma membrane and lateral plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; reproductive system; and sensory organ epithelium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]