Eif2s1 - eukaryotic translation initiation factor 2, subunit 1 alpha

Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of translational initiation in response to stress; and stress granule assembly. Acts upstream of or within protein autophosphorylation; regulation of translational initiation in response to stress; and translation. Located in cytoplasmic stress granule and nucleus. Is active in synapse. Is expressed in several structures, including brain ventricular layer; jaw; nose; orbito-sphenoid; and thymus primordium. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]