Efnb3 - ephrin B3

Predicted to enable ephrin receptor binding activity. Involved in negative regulation of axonogenesis and trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission. Acts upstream of or within T cell costimulation; adult walking behavior; and axon choice point recognition. Located in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study movement disease. Orthologous to human EFNB3 (ephrin B3). [provided by Alliance of Genome Resources, Apr 2022]