Eda - ectodysplasin-A

Predicted to enable death receptor agonist activity and death receptor binding activity. Acts upstream of or within several processes, including animal organ development; cell-matrix adhesion; and positive regulation of signal transduction. Located in apical part of cell and endoplasmic reticulum membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; future brain; nasal gland epithelium; and skin. Used to study hypohidrotic ectodermal dysplasia. Human ortholog(s) of this gene implicated in ectodermal dysplasia 1 and tooth agenesis. Orthologous to human EDA (ectodysplasin A). [provided by Alliance of Genome Resources, Apr 2022]