Dvl2 - dishevelled segment polarity protein 2

Enables several functions, including enzyme binding activity; frizzled binding activity; and identical protein binding activity. Involved in several processes, including outflow tract morphogenesis; positive regulation of GTPase activity; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of protein tyrosine kinase activity; and segment specification. Located in several cellular components, including apical part of cell; clathrin-coated vesicle; and lateral plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and retina. Used to study dextro-looped transposition of the great arteries. Orthologous to human DVL2 (dishevelled segment polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]