Drd2 - dopamine receptor D2

Enables G protein-coupled receptor activity; dopamine binding activity; and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in hyaloid vascular plexus regression; negative regulation of innate immune response; and regulation of neurotransmitter transport. Acts upstream of or within several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of ion transport. Located in several cellular components, including GABA-ergic synapse; dendrite; and dopaminergic synapse. Is integral component of postsynaptic membrane. Is active in glutamatergic synapse. Is integral component of presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study Parkinson's disease and primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including end stage renal disease; mental depression; migraine with aura; obesity; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2). [provided by Alliance of Genome Resources, Apr 2022]