Dlx5 - distal-less homeobox 5

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including endochondral ossification; osteoblast differentiation; and positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus. Acts upstream of or within several processes, including animal organ development; face morphogenesis; and positive regulation of macromolecule metabolic process. Located in chromatin; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; genitourinary system; and sensory organ. Used to study split hand-foot malformation 1. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 and split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5). [provided by Alliance of Genome Resources, Apr 2022]