Dlg1 - discs large MAGUK scaffold protein 1

Enables molecular adaptor activity and potassium channel regulator activity. A structural constituent of postsynaptic density. Involved in several processes, including neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of potassium ion transmembrane transport; and regulation of ventricular cardiac muscle cell action potential. Acts upstream of or within several processes, including animal organ development; hard palate development; and negative regulation of cell population proliferation. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and lateral loop. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and surface ectoderm. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]