Ddb1 - damage specific DNA binding protein 1

Predicted to enable several functions, including WD40-repeat domain binding activity; cullin family protein binding activity; and damaged DNA binding activity. Involved in cellular protein metabolic process; positive regulation of gluconeogenesis; and regulation of circadian rhythm. Acts upstream of or within Wnt signaling pathway and negative regulation of apoptotic process. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Cul4A-RING E3 ubiquitin ligase complex and Cul4B-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus and site of double-strand break. Is expressed in several structures, including liver; lung; otocyst; spermatocyte; and spleen. Orthologous to human DDB1 (damage specific DNA binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]