Daxx - Fas death domain-associated protein

Enables histone binding activity and transcription coactivator activity. Involved in nucleosome assembly; positive regulation of transcription by RNA polymerase II; and protein localization to chromatin. Acts upstream of or within several processes, including apoptotic signaling pathway; negative regulation of transcription, DNA-templated; and regulation of apoptotic process. Located in PML body and cytosol. Colocalizes with heterochromatin. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in islet cell tumor and ovary epithelial cancer. Orthologous to human DAXX (death domain associated protein). [provided by Alliance of Genome Resources, Apr 2022]