Cttn - cortactin

Predicted to enable several functions, including Arp2/3 complex binding activity; actin filament binding activity; and profilin binding activity. Involved in intracellular protein transport and regulation of autophagy of mitochondrion. Acts upstream of or within dendritic spine maintenance; negative regulation of extrinsic apoptotic signaling pathway; and substrate-dependent cell migration, cell extension. Located in several cellular components, including cytoskeleton; lamellipodium; and ruffle. Part of voltage-gated potassium channel complex. Is expressed in several structures, including 1-cell stage conceptus; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CTTN (cortactin). [provided by Alliance of Genome Resources, Apr 2022]