Ctcf - CCCTC-binding factor

Enables chromatin binding activity and sequence-specific DNA binding activity. Involved in regulation of gene expression and regulation of histone modification. Acts upstream of or within DNA metabolic process and regulation of gene expression. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and limb. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 21. Orthologous to human CTCF (CCCTC-binding factor). [provided by Alliance of Genome Resources, Apr 2022]