Ctbp2 - C-terminal binding protein 2

Enables several functions, including retinoic acid receptor binding activity; transcription coactivator activity; and transcription corepressor activity. A structural constituent of presynaptic active zone. Involved in negative regulation of transcription, DNA-templated; synaptic vesicle docking; and white fat cell differentiation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of chromatin binding activity; and positive regulation of retinoic acid receptor signaling pathway. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and photoreceptor ribbon synapse. Part of transcription repressor complex. Is active in presynaptic active zone cytoplasmic component and presynaptic cytosol. Is expressed in several structures, including alimentary system; limb; lung; nervous system; and retina layer. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]