Csf3r - colony stimulating factor 3 receptor (granulocyte)

Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within neutrophil chemotaxis and regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle membrane and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including bone marrow; dorsal aorta; early conceptus; gut; and reproductive system. Used to study hereditary neutrophilia. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). [provided by Alliance of Genome Resources, Apr 2022]