Crx - cone-rod homeobox

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and nuclear receptor binding activity. Involved in regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II and retina development in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; face; and nervous system. Used to study Leber congenital amaurosis 7. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox). [provided by Alliance of Genome Resources, Apr 2022]