Enables sequence-specific DNA binding activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; positive regulation of monocyte chemotaxis; and regulation of transcription, DNA-templated. Predicted to act upstream of or within chemotaxis and response to unfolded protein. Predicted to be located in several cellular components, including Golgi membrane; neuronal cell body; and nuclear body. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in nucleus. Is expressed in several structures, including 1st branchial arch; central nervous system; early conceptus; genitourinary system; and skeleton. Orthologous to human CREB3 (cAMP responsive element binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]