Socs3 - suppressor of cytokine signaling 3

Enables phosphotyrosine residue binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; negative regulation of insulin receptor signaling pathway; and placenta development. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in several structures, including extraembryonic component; liver; placenta; retina; and spleen. Human ortholog(s) of this gene implicated in atopic dermatitis 4. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Apr 2022]