Chuk - conserved helix-loop-helix ubiquitous kinase

Enables protein kinase activity. Involved in positive regulation of interferon-alpha production; protein phosphorylation; and response to virus. Acts upstream of or within several processes, including mammary gland development; osteoclast differentiation; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb. Used to study fetal encasement syndrome. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Apr 2022]