Chrm1 - cholinergic receptor, muscarinic 1, CNS

Enables neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within regulation of locomotion. Located in cholinergic synapse. Is active in Schaffer collateral - CA1 synapse. Is integral component of postsynaptic membrane. Is expressed in central nervous system; retina; and urinary system. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Apr 2022]